Home

Aging, stem cell differentiation, cancer metastasis, and inflammation rely on progressive changes in metabolism resulting in increased levels of reactive oxygen species. Collectively, the accumulation of these molecules is known as cellular oxidation, and pathological levels are referred to as oxidative stress. Our lab develops systems biology tools for investigating how cellular oxidation influences cellular decisions and intrepretation of cues from the extracellular environment. We are interested in the collective behavior that arises during stem cell differentiation, immune cell responses, or drug treatments from metabolic diversity in individual cells. Because of the numerous biochemical reactions involved, we develop computational models and analytical approaches to understand how complex protein networks are regulated in the presence of reactive oxygen species by changes in activity and/or function of redox-sensitive proteins. Experimentally, we are developing novel high-throughput single cell techniques for the detection and quantification of intracellular oxidation.



We are located in the Wallace H. Coulter Department of Biomedical Engineering administered jointly between Georgia Tech and Emory University School of Medicine. The lab is located on the Georgia Tech campus in the Engineered Biosystems Building.

10/19/17

Sarah Seals has been named one of 8 Georgia Tech Sloan Graduate Fellows for 2017 based upon her academic and research record! Sarah will receive a stipend bonus and professional development funds for the next 3 years (thus the remainder) of her PhD! Congratulations on this honor!

10/18/17

Melissa is a guest on the WREK 91.1 radio station show "Inside the Black Box", describing the lab's research to the metro Atlanta listeners.

10/13/17

Joshua Lewis received a Young Investigator travel award to attend the Society for Redox Biology & Medicine annual meeting. In addition, his abstract "Genome-scale modeling of NADPH metabolism in radiation-resistant head and neck squamous cell carcinoma patients" was selected for an oral presentation. Way to go, Josh!

9/21/17

Our collaborative project with co-PIs Cristina Furdui (Wake-Forest) and Dave Boothman (UTSW) has been awarded a 5 year U01 from NCI to develop predictive models of chemotherapeutic responses in head and neck cancer.

Lewis J.E., Costantini F., Mims J., Chen X., Furdui C., Boothman D.A., Kemp M.L. “Genome-scale modeling of NADPH-driven β-lapachone sensitization in head and neck squamous cell carcinoma”. Antioxidant Redox Signaling. doi:10.1089/ars.2017.7048, 2017.

Kniss-James, A.S., Rivet, C.A., Chingozha, L., Lu, H., Kemp, M.L. “Single-cell resolution of intracellular T cell Ca2+ dynamics in response to frequency-based stimulation”. Integrative Biology, DOI: 10.1039/C6IB00186F, 2017.

Prasanphanich, A.F., White, D.E., Gran, M.E., Kemp, M.L. “Kinetic Modeling of ABCG2 Transporter Heterogeneity: A Quantitative, Single-Cell Analysis of the Side Population Assay”. PLoS Computational Biology, Nov 16;12(11):e1005188, 2016.