Research

Our lab uses computational modeling and wet-lab experimentation in a broad portfolio of research projects in applications of regenerative medicine, cancer biology, immunoengineering, cellular manufacturing and precision medicine. A common thread among our projects is the development of new computational approaches for studying collective behavior in multicellular systems and the role of metabolism in influencing cellular  fate decisions in response to external cues. Please read more about our various projects below.

7/28/17

Sarah, Chad, Jakari, and Melissa attend the annual EBICS retreat at Calloway Gardens

7/1/17

Our lab is awarded an IBB seed grant in collaboration with Facundo Fernandez in Chemistry. Dr. Li Li and Sarah Seals will have internal funding to continue their amazing collaboration using the latest Bruker Rapiflex MALDI imager on campus! Here is a press release!

6/13/17

Kendrecus Weldon has joined the Kemp lab as our newest Project ENGAGES student and is mentored by Sarah Seals. Read here for more information on this amazing program. Our lab is proud to be participants!

Lewis J.E., Costantini F., Mims J., Chen X., Furdui C., Boothman D.A., Kemp M.L. “Genome-scale modeling of NADPH-driven β-lapachone sensitization in head and neck squamous cell carcinoma”. Antioxidant Redox Signaling. 2017 (in press).

Kniss-James, A.S., Rivet, C.A., Chingozha, L., Lu, H., Kemp, M.L. “Single-cell resolution of intracellular T cell Ca2+ dynamics in response to frequency-based stimulation”. Integrative Biology, DOI: 10.1039/C6IB00186F, 2017.

Prasanphanich, A.F., White, D.E., Gran, M.E., Kemp, M.L. “Kinetic Modeling of ABCG2 Transporter Heterogeneity: A Quantitative, Single-Cell Analysis of the Side Population Assay”. PLoS Computational Biology, Nov 16;12(11):e1005188, 2016.